TGIF1 is a negative regulator of MLL-rearranged …
TGIF1 expression is downregulated in MLL-rearranged leukemias. TGIF1 has been reported to restrict self-renewal and quiescence of HSCs, but otherwise its function in normal and malignant ...
Malignant hematopoietic cell lines: in vitro models for the …
A second type of MLL gene alteration is the partial tandem duplication (PTD), which occurs in acute myeloid leukemia (AML). We found four AML cell lines with an …
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Funding Centre for Social Welfare and Health Organisations (STEA) supports the work of the Mannerheim League for Child Welfare and the League organizes annual fund …
Licensed to elongate: a molecular mechanism for MLL-based …
a | Protein domain structure of mixed lineage leukaemia (MLL) chimaeras. The amino terminus of MLL is fused with the carboxyl terminus of a fusion partner. The …
Inhibitors of the Menin-Mixed Lineage Leukemia …
A series of lead structures identified from a High Throughput Screen (HTS) targeting the Menin-Mixed Lineage Leukemia (MLL) protein-protein interaction are reported. Two chemical series have been …
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The KMT2A recombinome of acute leukemias in 2023
Chromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo as well as therapy-induced infant, pediatric, and adult acute …
MLL-Rearranged Leukemias—An Update on Science and …
After its translation, wild-type MLL1 is proteolytically cleaved by the enzyme taspase-1 (19, 20).The resulting 320-kDa N-terminal fragment (MLL-N) contains all …
Structure, function and inhibition of critical protein–protein
Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a …
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Molecular and Epigenetic Mechanisms of MLL in Human …
2. MLL in Normal Hematopoiesis. MLL was originally identified as a functional ortholog of the trithorax gene in Drosophila [39,40,41].Wild type MLL is crucial …
Therapeutic Targeting of MLL Degradation Pathways in MLL …
Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner genes result in aggressive leukemia with dismal outcomes.Despite similar expression at …
Stabilizing the Mixed Lineage Leukemia Protein | NEJM
The translocation of the gene encoding mixed lineage leukemia with other genes results in chimeric, oncogenic proteins. A recent study shows that stabilization of …
Challenges and opportunities in targeting the menin-MLL interaction
The oncogenic function of MLL fusion proteins is critically dependent on their direct interaction with menin [17, 18].Menin is a 67 kDa protein encoded by the MEN1 (Multiple …
MLL-Rearranged Acute Lymphoblastic Leukemia
Purpose of Review Rearrangements of the histone lysine [K]-MethylTransferase 2A gene (KMT2A) gene on chromosome 11q23, formerly known as …
Selective Killing of Mixed Lineage Leukemia Cells by a Potent …
Mislocated enzymatic activity of DOT1L has been proposed as a driver of leukemogenesis in mixed lineage leukemia (MLL). The characterization of EPZ004777, a potent, selective …
Phosphorylation of MLL by ATR is required for execution of …
Leukaemogenic MLL translocations fuse the common MLL amino-terminal 1,400 amino acids in frame with more than 60 partners 8.The MLL gene encodes a 500 …
Molecular pathogenesis of disease progression in MLL
Whole exome sequencing (WES) of mouse MLL/AF9-AML.a, b Upper panels showed 12 and 13 mice analyzed by WES in strain A1 and B1, respectively. Middle …
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MLL Legal is a leading Swiss law firm with a history that dates back to 1885. The firm has grown both organically and by means of strategic mergers, the latest of which took place on 1st July 2021 between …
HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated …
MLL-HBO1 complex association is mediated by multiple contacts and in a chromatin-bound context containing H3K4 methylation. (A) Association of the MLL bait …
About us | MLL
MLL MVZ was formed in 2021 by changing the name of MHP Münchner Hämatologiepraxis, which was founded in 2005. The MLL MVZ (Medical Care Center for …
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent …
MLL is involved in chromosomal translocations associated with leukemia. Remarkably, MLL is involved in translocations with >50 different genes (1, 2).MLL is …
Structure of the MLL CXXC domain–DNA complex and its functional …
MLL fusions are linked to leukemias and retain the CXXC domain, which binds unmethylated DNA. The NMR structure of CXXC–DNA now indicates the …
THE PREMIER LACROSSE LEAGUE AND MAJOR LEAGUE LACROSSE …
LOS ANGELES (December 16, 2020) – The Premier Lacrosse League ("PLL") and Major League Lacrosse ("MLL") have merged with subsequent season operations and …
MLL | definition of MLL by Medical dictionary
MLL: A gene on chromosome 2q11.2-q12 that encodes a DNA-binding protein which methylates histone H3 and upregulates expression of target genes, including multiple …
Stabilizing the Mixed Lineage Leukemia Protein
Figure 1. Stabilizing the Mixed-Lineage Leukemia (MLL) Protein. To evaluate the therapeutic potential of wild-type MLL stabilization through IRAK inhibition, Liang et al. tested the activity of ...
MLL portal for diagnostic reports:
In the MLL portal for diagnostic reports, we make all diagnostic reports from your clinic/practice (since 2017) available to you digitally and up-to-date to the minute. New or older reports can be opened and downloaded with …
Pharmacologic Inhibition of the Menin-MLL …
Chromosomal translocations of MLL occur in aggressive acute leukemias affecting both children and adults. MLL fusion proteins require menin for leukemogenic activity, and selective targeting of the …
Cell of origin determines clinically relevant subtypes of MLL …
MLL-AF9-transduced single HSCs or GMPs could be continuously replated, but HSC-derived clones were more likely than GMP-derived clones to initiate AML in …
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